Harry Weber was born in St. Louis, Missouri, in 1942. He earned an English degree from Princeton University and served six years in the United States Navy, including a year-long tour commanding River Patrol Boats in Vietnam, where he was awarded the Bronze Star with V for valor and the Presidential Unit Citation.

As a sculptor, Weber has gained an international reputation. His body of work includes over 150 large, commissioned sculptures displayed publicly in twenty-seven states, the Bahamas, China, and Africa. These works feature historical figures and notable individuals from the arts, politics, and sports scenes. Two of his sculpture groups have been designated National Lewis and Clark sites by the National Park Service. He was chosen through a national competition to create a statue of Dred and Harriet Scott, which now stands in front of the Old Courthouse where the historic decision was made. His sculptures of famous sports figures are prominent features at fifteen different professional and amateur stadiums, including Busch Stadium in St. Louis, Kauffman Stadium in Kansas City, Choctaw Stadium in Arlington, and TD Garden in Boston.

In 2023, Weber received a Star on the St. Louis Walk of Fame, which honors individuals from St. Louis who have made significant contributions to American culture. He has also been inducted into the St. Louis Sports Hall of Fame and the Missouri Sports Hall of Fame.